Admira MR Tablet

✔️ Uses of Admira MR Tablet

• Treatment of Type 2 Diabetes Mellitus

✔️ How does Admira MR Tablet work?

Admira MR Tablet works by increasing the release of insulin from your pancreas (a part of your digestive system that produces insulin and other vital enzymes). Thus it lowers your blood sugar levels.

✔️ Side Effects of Admira MR Tablet

• Diarrhea
• Constipation
• Stomach ache or indigestion
• Nausea)
• Vomiting)
• Hypoglycemia (low blood sugar levels)

✔️ Quick Suggestions:

• Eat Regularly: Avoid long gaps between meals or snacks.
• Monitor Blood Sugar: Regularly check levels, especially during fluctuations.
• Gradual Weight Loss: Aim for a healthy BMI (18.5-24.9).
• Healthy Fats: Cut saturated fat; opt for omega-3 oils in cooking.
• Stress Management: Use mindfulness, yoga, or meditation to control stress.
• Blood Pressure: Keep it normal (120/80mmHg) to lower cardiovascular risk.
• Follow Directions: Take Admira MR Tablet as prescribed; avoid self-medicating.
• Stay Informed: Learn early signs of high/low blood sugar from your doctor.

✔️ Indication of Admira MR Tablet

Admira MR Tablet is used to treat maturity-onset diabetes, and diabetes with or without obesity in adults when diet, exercise, weight loss, or insulin therapy fail to provide adequate results.

✔️ Pharmacology

Gliclazide, a second-generation sulfonylurea, holds hypoglycemic and potential hematological impacts. It curbs the liver's glucose production, concurrently spurring insulin secretion from pancreatic β-cells. This is achieved by enhancing Ca+2 transportation across the β-cell membranes.

✔️ Dosage & Administration of

• The usual starting dose of Gliclazide is 40 to 80 mg per day in the form of a film-coated tablet. If necessary, the dosage can be increased to a maximum of 320 mg daily, split into multiple doses. It's important to take the medication before a meal. Gliclazide is not suitable for children and is contraindicated in juvenile-onset diabetes.
• Gliclazide 30 mg is typically taken as 1 to 4 tablets per day, while Gliclazide 60 mg is taken as 1 to 2 tablets per day in a single dose. It's recommended to take the medication in the morning, preferably before breakfast, to minimize the risk of stomach issues.
• If you miss a dose of Admira MR Tablet, try to take it as soon as you remember. If it's close to the time for your next dose, skip the missed one and continue with your regular dosing schedule. Avoid doubling the dose to make up for the missed one, and remember not to skip your blood sugar medicines.
• In case of overdose, symptoms like low blood pressure, headache, dizziness, sweating, hunger, shakiness, weakness, double vision, confusion, and palpitations might occur. Seek immediate medical attention if you suspect an overdose of Admira MR Tablet or experience such symptoms.

✔️ Interaction

Certain medications can interact with Gliclazide, affecting its hypoglycemic (blood sugar-lowering) effects:

Enhancing Hypoglycemic Effects:

• Aspirin
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
• Phenylbutazone
• Clofibrate
• Sulfonamide
• Cimetidine
• Imidazole antifungal medications
• Monoamine Oxidase inhibitors (MAOIs)

Decreasing Hypoglycemic Effects:

• Rifampin
• Barbiturates
• Phenytoin
• Thiazide diuretics
• Diazoxide
• Glucocorticoids
• Estrogens
• Sympathomimetic medications
• Alcohol

✔️ Contraindications

Juvenile-Onset (Type-1) Diabetes: Gliclazide is not suitable for individuals with type-1 diabetes, which is characterized by the inability of the pancreas to produce insulin.

Diabetes Associated with Ketosis: Gliclazide is not recommended for diabetes patients experiencing ketosis, a condition where the body burns fat for energy due to insufficient insulin.

Diabetic Patients Undergoing Surgery, Severe Injury, or Infection: Gliclazide should be avoided in diabetic patients who are undergoing surgery, have experienced a severe injury, or are dealing with infections, as their medical conditions may affect the use of the medication.

Hypersensitivity to Sulfonylurea Group: If a patient has a known hypersensitivity or allergy to drugs in the sulfonylurea group, Gliclazide should not be used.

Pregnancy and Breastfeeding: Gliclazide is not recommended for pregnant or breastfeeding women due to potential risks to the fetus or infant.

Hepatic Insufficiency: Gliclazide should be avoided in patients with severe liver insufficiency.

✔️ Pregnancy & Lactation

Pregnant women should avoid using gliclazide. It should not be used by a woman who is breastfeeding.

✔️ Precautions & Warnings

• Monitor Blood Glucose: Regularly monitor your blood glucose levels as directed by your healthcare provider. This helps to ensure your diabetes is well-managed and adjust your treatment plan if needed.
• Insulin During Metabolic Stress: In situations of metabolic stress (e.g., illness, surgery), you may require insulin in addition to Gliclazide to manage blood glucose levels effectively. Consult your doctor in such cases.
• Transition from Combination Therapy: If you are transitioning from a combination therapy involving Gliclazide, your healthcare provider will guide you through the process to ensure a smooth transition and proper management of your diabetes.
• Risk of Severe Hypoglycemia: Elderly individuals, debilitated patients, and those with hepatic or renal impairment are at an increased risk of severe hypoglycemia (low blood sugar). Extra caution and monitoring are advised in these populations.
• Hypoglycemia Risk Factors: Be aware of situations that may increase the risk of hypoglycemia, such as inadequate caloric intake, strenuous exercise, alcohol consumption, or the use of multiple antidiabetic drugs simultaneously.

✔️ Storage Conditions

• Store Admira MR Tablet below 25°C at a dry place, protected from light.
• Keep it away from children and pets.